Predicate: upregulate

Roleset id: upregulate.01 , increase a cellular response to a molecular stimulus, Source: , vncls: , framnet:

upregulate.01: UPREGULATE-V NOTES: Created for Bio-AMR annotations.

Aliases:

AliasFrameNetVerbNet
upregulate (v.)
upregulation (n.)

Roles:

        Arg0-PAG: intentional agent of upregulation (e.g. scientist)
        Arg1-PPT: thing upregulated (e.g. protein or another molecule)
        Arg2-MNR: instrument (e.g. enzyme)

Example: upregulate-v: active use, with instrument

        We found that TGF-� upregulates CD70 expression on effector Tm cells while it preferentially induces Foxp3 expression in naive T cells.

        Arg2: TGF-�
        Rel: upregulates
        Arg1: CD70 expression on effector Tm cells

Example: upregulate-v: with agent

        For this purpose, we upregulated miR-639 and this treatment led to an approximately 2-fold augmentation in invasive properties (Figure 3A).

        Argm-prp: For this purpose
        Arg0: we
        Rel: upregulated
        Arg1: miR-639

Example: upregulation-n

        Has anyone here ever heard of the upregulation of genes?

        Rel: upregulation
        Arg1: of genes