Predicate: dysregulate
Roleset id: dysregulate.01 , impair a physiological regulatory mechanism, Source: , vncls: , framnet:
dysregulate.01: DYSREGULATE-V NOTES: Created for Bio-AMR annotations.
Aliases:
| Alias | FrameNet | VerbNet |
|---|
| dysregulate (v.) | | |
| dysregulation (n.) | | |
Roles:
Arg0-PAG: agent of dysregulation (e.g. scientist)
Arg1-PPT: thing dysregulated (e.g. signaling)
Arg2-MNR: instrument (e.g. protein, drug)
Example: dysregulate-v: with instrument
E1A expression dysregulates IL-8 production and suppresses IL-6 production by lung epithelial cells.
Arg2: E1A expression
Rel: dysregulates
Arg1: IL-8 production
Example: dysregulate-v: with all arguments
To determine whether a more physiological level of RipA could be converted to a lethal autolysin, we dysregulated RipA activity through the use of the beta-lactam antibiotic meropenem.
Argm-prp: To determine whether a more physiological level of RipA could be converted to a lethal autolysin
Arg0: we
Rel: dysregulated
Arg1: RipA activity
Arg2: through the use of the beta-lactam antibiotic meropenem
Example: dysregulation-n
Addiction is presented as a cycle of spiralling dysregulation of brain reward systems
Argm-adj: spiralling
Rel: dysregulation
Arg1: of brain reward systems