Predicate: downregulate

Roleset id: downregulate.01 , reduce a cellular response to a molecular stimulus, Source: , vncls: , framnet:

downregulate.01: DOWNREGULATE-V NOTES: Created for Bio-AMR annotations.

Aliases:

AliasFrameNetVerbNet
downregulate (v.)
downregulation (n.)

Roles:

        Arg0-PAG: intentional agent of downregulation (e.g. scientist)
        Arg1-PPT: thing downregulated (e.g. protein or another molecule)
        Arg2-MNR: instrument (e.g. enzyme)

Example: downregulate-v: example with instrument

        The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

        Arg2: The two-handed E box binding zinc finger protein SIP1
        Rel: downregulates
        Arg1: E-cadherin

Example: downregulate-v: with intentional agent

        In this study, we downregulated miR-34s in human mesothelial cells to investigate the cellular effect of miR-34 knockdown.

        Argm-loc: In this study
        Arg0: we
        Rel: downregulated
        Arg1: miR-34s in human mesothelial cells
        Argm-prp: to investigate the cellular effect of miR-34 knockdown

Example: downregulation-n

        Some receptor agonists may cause downregulation of their respective receptor(s),

        Rel: downregulation
        Arg1: of their respective receptor(s)