misfortune-n; 2 Senses

Sense Number 1: a specific adverse event, instance of bad luck

Commentary: MISFORTUNE[+event][+adverse]
NOTE: refers to specific instances of bad luck these can include humorous events, unlike Sense 2.

Bob had the misfortune to break his leg right before his vacation.
By misfortune, the manuscript was lost en route to the publisher.
It's a comedy about the misfortunes of planning a big wedding. (a series of mishaps)

WordNet 3.0 Sense Numbers: 1

Sense Number 2: a chronic state of adversity, hard times

Commentary: MISFORTUNE[+state][+circumstance][+chronic][+adversity]
NOTE: implies ongoing serious, even tragic, adversity - more intense than what is implied by Sense 1

She helped many people through their times of misfortune.
They never lost hope even in the depths of misfortune.
He couldn't see past the misfortune of his current circumstances.

WordNet 3.0 Sense Numbers: 2