irritation-n; 5 Senses

Sense Number 1: a state of annoyance, vexation

Commentary: IRRITATION[+state][+emotional][+annoyance]
NOTE: attributes an emotional state to a person

Her irritation grew as the minutes went by and the bus still didn't come.
Any irritation she may have felt earlier was dispelled by the bouquet of roses.

WordNet 3.0 Sense Numbers: 1, 2

Sense Number 2: the act of annoying someone or something

Commentary: IRRITATION[+action][+annoy]
NOTE: nominalization - the child's irritation of everyone - the child irritated everyone.
NOTE: refers to an agent's -act- of irritating, not the agent itself (Sense 3)

The child's irritation of the entire cabin of the plane lasted for hours.
The thistle's irritation of his back under the saddle caused the horse to buck.

WordNet 3.0 Sense Numbers: 6, 7

Sense Number 3: a cause or agent of annoyance

Commentary: IRRITATION[+cause][+effective][+annoyance]
NOTE: refers to the cause or agent of annoyance.

These are just some of the minor irritations of life.
Let me know if little Johnny becomes a major irritation at the day care center.

WordNet 0.0 Sense Numbers: 1b

Sense Number 4: physiological: abnormal, painful sensitivity

Commentary: IRRITATION[+state][+physiological][+condition][-normal][+sensitivity][+inflammation/+swelling]
NOTE: abnormal condition of pain, inflammation, sensitivity

The irritation in Mary's eyes is from tree pollen.
This salve will soothe the irritations on your arms.
The doctor could not determine what had caused the patient's stomach irritation.

WordNet 3.0 Sense Numbers: 3, 5

Sense Number 5: physical excitation of a biological entity

Commentary: IRRITATION[+event][+physiological][+response][+excitation][+normal][+cell/+organ/+organism]
NOTE: a normal reaction of a living organism or cell to outside stimulation

The cells reacted to the irritation of outside electrical stimulation.
The irritation from the cold caused the muscle to contract.

WordNet 3.0 Sense Numbers: 4